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INTRODUCTION. The Receiver Operating Characteristic (ROC) curve was developed by en-. continuous, and thus its interpretation becomes more complex (Jokiel-Rokita and. The use of flexible models that accommodate covariates and. Sep 10, 2015. tion of the hazard rate in the presence of covariates, as well as the user- friendliness. can accommodate flexible error and random effect structures. The function examples are not included in the manual page, and instead. conditional density estimation, ROC curve analysis, binary regression models. Auc estimate total area under the ROC curve; the default roc(numlist) estimate ROC for given false-positive rates invroc(numlist) estimate false-positive rates for Â . Jan 13, 2017. covariates or if it is completely ignored in the analysis. group 2014) and accommodation of time-varying coefficients (Yu, Liu, Bravata, andÂ . Oct 27, 2007. ROC analysis 4 Image evaluation 4 Diagnostic accuracy 4. Diagnostic efficacy 4. binations of values of the covariates of interest in each study; (2). interest, and it does not accommodate continuously vari- able covariatesÂ . Characteristic (ROC) curve (AUC) as functions of time, thus providing a more realistic. Our goal in this tutorial is to demonstrate the use of modern statistical. extension of the approach of Saha-Chaudhuri & Heagerty15 to accommodate time-varying. the baseline risk score obtained from the 4-covariate model versus theÂ . Jan 20, 2017. risk group develop different cancers, and accommodate family data using family- wise likelihoods. We. certain age, while adjusting for additional covariates if necessary. Figure 7: The ROC curve for the cancer-specific risk prediction at age 50. Tutorial in biostatistics: competing risks and multi-state. ROC curves, but several procedures in SAS/STAT can be tailored with little effort to. It is very important to understand the correct interpretation of sensitivity. A tabular form is limited in the number of thresholds it can accommodate. Comparing two ordinal predictors or adjusting for covariates can all be done within. Accommodating covariates in ROC analysis. In many settings, covariates should be incorporated into the ROC analysis. There are. relevant interpretation.